| Immunogen | Humanmelanomacellline(Ross,1984). |
| Epitope | withina.a.1-160,extracellulardomainofhp75. |
| Clone | ME20.4 |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Reactswiththelowaffinitynervegrowthfactorreceptor(NGFRp75).Theepitoperecognizedbytheantibodymapswithinthethirdorfourthcysteine-richrepeatsoftheNGFRmolecule.Reactivityhasnotbeenobservedwithrat,chicken,ormouseNGFR. |
| Isotype | IgG1 |
| SpeciesReactivity | - Canine
- Human
- Pig
- Rabbit
- Sheep
- Feline
- Primate
- Raccoon
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Nervegrowthfactorreceptorcontainsanextracellulardomaincontainingfour40-aminoacidrepeatswith6cysteineresiduesatconservedpositionsfollowedbyaserine/threonine-richregion,asingletransmembranedomain,anda155-aminoacidcytoplasmicdomain.Thecysteine-richregioncontainsthenervegrowthfactorbindingdomain. |
| GeneSymbol | - NGFR
- p75(NTR)
- TNFRSF16
- Gp80-LNGFR
- CD271
|
| Non-ReactiveSpecies | |
| PurificationMethod | ProteinAPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P08138#LowaffinityreceptorwhichcanbindtoNGF,BDNF,NT-3,andNT-4.Canmediatecellsurvivalaswellascelldeathofneuralcells. SIZE:427aminoacids;45183Da SUBUNIT:Homodimer;disulfide-linked.Interactswithp75NTR-associatedcelldeathexecutor.InteractswithTRAF2,TRAF4,TRAF6,PTPN13andRANBP9.InteractsthroughTRAF6withSQSTM1whichbridgesNGFRtoNTRK1.InteractswithBEX1andNGFRAP1/BEX3. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. DOMAIN:SwissProt:P08138DeathdomainisresponsIBLeforinteractionwithRANBP9. PTM:N-andO-glycosylated.&O-linkedglycansconsistofGal(1-3)GalNAccoreelongatedby1or2NeuNAc.&Phosphorylatedonserineresidues. SIMILARITY:Contains1deathdomain.&Contains4TNFR-Cysrepeats. |
| MolecularWeight | ~69-75kDa |