| Immunogen | Ratbrainsynaptotagmin. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Mouse |
| Specificity | Synaptotagmin1,alsoknownasp65.ByWesternblotMAB5200reactswithasingleproteinwithamolecularweightofapproximately65kDa.MAB5200hasnotbeenepitopemapped. |
| Isotype | IgG2a |
| SpeciesReactivity | - Bovine
- Chicken
- Mouse
- Rat
- Rabbit
- Frog
- Shark
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | ThesynaptotagminsareintegralmembraneproteinsofsynapticvesiclesthoughttoserveasCa(2+)sensorsintheprocessofvesiculartraffickingandexocytosis.CalciumbindingtosynaptotagminIparticipatesintriggeringneurotransmitterreleaseatthesynapse(Fernandez-Chaconetal.,2001[PubMed11242035]).[suppliedbyOMIM] |
| GeneSymbol | - SYT1
- DKFZp781D2042
- SVP65
- SytI
- SYT
- p65
- P65
- Synaptotagmin-1
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P21579#Mayhavearegulatoryroleinthemembraneinteractionsduringtraffickingofsynapticvesiclesattheactivezoneofthesynapse.Itbindsacidicphospholipidswithaspecificitythatrequiresthepresenceofbothanacidicheadgroupandadiacylbackbone.ACa(2+)-dependentinteractionbetweensynaptotagminandputativereceptorsforactivatedproteinkinaseChasalsobeenreported.ItcanbindtoatleastthreeadditionalproteinsinaCa(2+)-independentmanner;theseareneurexins,syntaxinandAP2. COFACTOR:Binds3calciumionspersubunit.TheionsareboundtotheC2domains(Bysimilarity). SIZE:422aminoacids;47573Da SUBUNIT:Homotetramer(Probable).InteractswithSTN2,SV2A,SV2B,SV2CandRIMS1.FormsacomplexwithSV2B,syntaxin1andSNAP25(Bysimilarity). SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesicle.Cytoplasmicvesicle,secretoryvesicle,chromaffingranule.Note=Synapticvesiclesandchromaffingranules. DOMAIN:SwissProt:P21579ThefirstC2domainmediatesCa(2+)-dependentphospholipidbinding.&ThesecondC2domainmediatesinteractionwithSV2AandSTN2(Bysimilarity). SIMILARITY:Belongstothesynaptotagminfamily.&Contains2C2domains. |