| Immunogen | Crudesynapticimmunoprecipitate(Human). |
| Clone | SP10 |
| Host | Mouse |
| Specificity | Synaptobrevin[VAMP].MAB333reactswithVAMP-1andVAMP-2fusionproteinexpressedinbacterialsystem. |
| Isotype | IgM |
| SpeciesReactivity | - Human
- Hamster
- Pig
- Rat
- Salamander
|
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Synaptobrevins/VAMPs,syntaxins,andthe25-kDsynaptosomal-associatedproteinSNAP25arethemaincomponentsofaproteincomplexinvolvedinthedockingand/orfusionofsynapticvesicleswiththepresynapticmembrane.VAMP1isamemberofthevesicle-associatedmembraneprotein(VAMP)/synaptobrevinfamily.Multiplealternativesplicevariantsthatencodeproteinswithalternativecarboxyendshavebeendescribed,butthefull-lengthnatureofsomevariantshasnotbeendefined. |
| GeneSymbol | - VAMP1
- SYB1
- Synaptobrevin-1
- VAMP-1
- DKFZp686H12131
|
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P23763#Involvedinthetargetingand/orfusionoftransportvesiclestotheirtargetmembrane. SIZE:118aminoacids;12902Da SUBUNIT:InteractswithVAPAandVAPB. SUBCELLULARLOCATION:Isoform1:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane;Single-passtypeIVmembraneprotein(Bysimilarity).&Isoform2:Cytoplasmicvesiclemembrane;Single-passtypeIVmembraneprotein(Bysimilarity).&Isoform3:Mitochondrionoutermembrane;Single-passtypeIVmembraneprotein. TISSUESPECIFICITY:Nervoussystem,skeletalmuscleandADIposetissue. SIMILARITY:SwissProt:P23763##Belongstothesynaptobrevinfamily.&Contains1v-SNAREcoiled-coilhomologydomain. |