| Immunogen | PurifiedhumanTcells |
| Clone | UCHT1 |
| Host | Mouse |
| Specificity | Thisantibodyrecognizes22/26/30kDamolecularweightlymphocytesurfacemoleculesassociatedwiththeTcellantigenreceptorcomplex.ItreactswiththemajorityofperipheralbloodTlymphocytes,amajorproportionofthymocytes,themajorityofTcellchroniclymphocyticleukaemiacells,Sézaryleukaemiasandapproximately70%ofacutelymphoblasticleukaemiasofTcellorigin. Antigendistribution: Tcells100% PeripheralBloodlymphocytes75+7% Thymocytes68+5% Granulocytes<> Monocytes<> Bcells(E-)<> NKcells(CD16+)<> KNOWNSPECIESCROSSREACTIVITY:Negativewithrhesusmonkeyperipheralbloodleucocytesinflowcytometry FUSIONPARTNER:P3x63Ag8.653myelomacellline |
| Isotype | IgG1 |
| SpeciesReactivity | |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | TheproteinencodedbythisgeneistheCD3-epsilonpolypeptide,whichtogetherwithCD3-gamma,-deltaand-zeta,andtheT-cellreceptoralpha/betaandgamma/deltaheterodimers,formstheT-cellreceptor-CD3complex.Thiscomplexplaysanimportantroleincouplingantigenrecognitiontoseveralintracellularsignal-transductionpathways.Thegenesencodingtheepsilon,gammaanddeltapolypeptidesarelocatedinthesameclusteronchromosome11.TheepsilonpolypeptideplaysanessentialroleinT-celldevelopment.Defectsinthisgenecauseimmunodeficiency.ThisgenehasalsobeenlinkedtoasusceptibilitytotypeIdiabetesinwomen. |
| GeneSymbol | |
| Non-ReactiveSpecies | |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07766#TheCD3complexmediatessignaltransduction. SIZE:207aminoacids;23147Da SUBUNIT:TheTCR/CD3complexofT-lymphocytesconsistsofeitheraTCRalpha/betaorTCRgamma/deltaheterodimercoexpressedatthecellsurfacewiththeinvariantsubunitsofCD3labeledgamma,delta,epsilon,zeta,andeta. SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein. SIMILARITY:SwissProt:P07766##Contains1Ig-like(immunoglobulin-like)domain.&Contains1ITAMdomain. |