| Immunogen | RecombinantproteinfromthecytoplasmictailofmouseCrim1. |
| Host | Rabbit |
| Specificity | Crim1
SUBCELLULARLOCALIZATION:IntracellularandMembraneassociated. |
| SpeciesReactivity | |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Motorneuronsareamongtheearliestneuronstoappearafterthecommencementofcellpatterningandthebeginningofcelldifferentiation.Differentiationoccursinaventral-to-dorsalgrADIentandismediated,atleastinpart,bytheconcentrationofventrallyexpressedsonichedgehogprotein(SHH;MIM600725).Dorsallyexpressedfactors,suchasmembersofthebonemorphogenicprotein(e.g.,BMP4;MIM112262)andtransforminggrowthfactor-beta(e.g.,TGFB1;MIM190180)families,canrepresstheinductionoftheseneurons.CRIM1mayinteractwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival(Kolleetal.,2000[PubMed10642437]).[suppliedbyOMIM] |
| GeneSymbol | |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:Q9NZV1#MayplayaroleinCNSdevelopmentbyinteractingwithgrowthfactorsimplicatedinmotorneurondifferentiationandsurvival.Mayplayaroleincapillaryformationandmaintenanceduringangiogenesis.ModulatesBMPactivitybyaffectingitsprocessinganddeliverytothecellsurface. SIZE:1036aminoacids;113738Da SUBUNIT:InteractswithBMP4andBMP7. SUBCELLULARLOCATION:Processedcysteine-richmotorneuron1protein:Secreted.&Cellmembrane;Single-passtypeImembraneprotein. TISSUESPECIFICITY:Expressedinpancreas,kidney,skeletalmuscle,lung,placenta,brain,heart,spleen,liverandsmallintestine.Expressedinbloodvessels(atproteinlevel). PTM:N-glycosylated. SIMILARITY:SwissProt:Q9NZV1##Contains4antistasin-likedomains.&Contains1IGFBPN-terminaldomain.&Contains6VWFCdomains. |