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Millipore/AB5541 | Anti-Glial Fibrillary Acidic Protein Antibody/AB5541/50 µL
  • Millipore/AB5541 | Anti-Glial Fibrillary Acidic Protein Antibody/AB5541/50 µL

Millipore/AB5541 | Anti-Glial Fibrillary Acidic Protein Antibody/AB5541/50 µL

價(jià)格: ￥4188.00 市場(chǎng)價(jià): 6980.00
貨號(hào): AB5541
品牌: Millipore
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    • Description
      CatalogueNumberAB5541
      Replaces04-1031;04-1062
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-GlialFibrillaryAcidicProteinAntibody
      AlternateNames
      • GFAP
      BackgroundInformationGlialfibrillaryacidicprotein(GFAP)isaclass-IIIintermediatefilament.TypeIIIintermediatefilamentscontainthreedomains,themostconservedofwhichistheroddomain.ThespecificsequenceforthisregionoftheproteinmaydifferbetweenthedifferentintermediatefilamentgenesfortypeIIIproteins,butthestructureoftheproteinishighlyconserved.GFAPisthemainconstituentofintermediatefilamentsinastrocytesandservesasacellspecificMarkerthatdistinguishesdifferentiatedastrocytesfromotherglialcellsduringthedevelopmentofthecentralnervoussystem.GFAPisalsofoundinthelensepithelium,Kupffercellsoftheliver,insomecellsinsalivarytumorsandhasbeenreportedinerythrocytes.
      ProductInformation
      FormatAffinityPurified
      Control
      • Astrocytes,astrocytomas,neuralstemcells.
      PresentationPurifiedchickenpolyclonalinbuffercontainingPBScontaining5mMsodiumazide.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cinundilutedaliquotsfromdateofreceipt.Donotstoreinaself-defrostingfreezer.

      HandlingRecommendations:
      Uponfirstthaw,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationThisAnti-GlialFibrillaryAcidicProteinAntibodyisvalidatedforuseinIC,IH,IH(P),WBforthedetectionofGFAP.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry
      • Immunohistochemistry(Paraffin)
      • WesternBlotting
      ApplicationNotesImmunohistochemistry(paraffin):
      Representativeimagesfromapreviouslot.PicturesofOptimalStainingWithCitrateBufferEpitopeRetrieval:HumanBrain.

      Immunocytochemistry:
      1:200-1:1,000oncellsintissueculturefixedforoneminutein3.7%formalinandoneminutein-20°Cmethanol.

      Westernblot:
      1:100-1:500usingECL.Recognizesabandof55kDa.Mayalsoreactwithabandof50kDa.

      Immunohistochemistry:
      1:100-1:500onfrozentissuesections.Suggestedfixativeis4%paraformaldehyde.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.

      STAININGPATTERN:

      Theantibodystainssharplydefinedcytoplasmicfilamentsofastrogliacellsintissueculture.Stainsprocessesofastrocytesinsectionsofbraintissues.
      BIOLOGicalInformation
      ImmunogenPurifiedbovineGFAP.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostChicken
      SpecificityGlialfibrillaryacidicprotein(GFAP).Reactswithbothnativeandrecombinantprotein.
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Bovine
      • Pig
      SpeciesReactivityNoteHuman,rat,andmouse.Expectedtocross-reactwithbovineandporcine.Otherspecieshavenotyetbeentested.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneencodesoneofthemajorintermediatefilamentproteinsofmatureastrocytes.Itisusedasamarkertodistinguishastrocytesfromotherglialcellsduringdevelopment.MutationsinthisgenecauseAlexanderdisease,araredisorderofastrocytesinthecentralnervoussystem.Anadditionaltranscriptvarianthasbeendescribed,butitsfulllengthsequencehasnotbeendetermined.
      GeneSymbol
      • GFAP
      • FLJ45472
      PurificationMethodImmunoAffinityPurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P14136#GFAP,aclass-IIIintermediatefilament,isacell-specificmarkerthat,duringthedevelopmentofthecentralnervoussystem,distinguishesastrocytesfromotherglialcells.
      SIZE:432aminoacids;49880Da
      SUBUNIT:Isoform3interactswithN-terminusofPSEN1.
      SUBCELLULARLOCATION:Cytoplasm.Note=Associatedwithintermediatefilaments.
      DISEASE:SwissProt:P14136#DefectsinGFAPareacauseofAlexanderdisease[MIM:203450].Alexanderdiseaseisararedisorderofthecentralnervoussystem.ItisaprogressiveleukoencephalopathywhosehallmarkisthewidespreadaccumulationofRosenthalfiberswhicharecytoplasmicinclusionsinastrocytes.Themostcommonformaffectsinfantsandyoungchildren,andischaracterizedbyprogressivefailureofcentralmyelination,usuallyleADIngtodeathusuallywithinthefirstdecade.InfantswithAlexanderdiseasedevelopaleukoencephalopathywithmacrocephaly,seizures,andpsychomotorretardation.Patientswithjuvenileoradultformstypicallyexperienceataxia,bulbarsignsandspasticity,andamoreslowlyprogressivecourse.
      SIMILARITY:SwissProt:P14136##Belongstotheintermediatefilamentfamily....
      MolecularWeight55kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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