| Immunogen | SyntheticpeptidefromratVGLUT3protein. |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | GuineaPig |
| Specificity | RecognizesVesicularGlutamateTransporter3(VGLUT3).Theantiserumhasbeentestedontissuesectionsfromtheratcentralnervoussystem(CNS)usingimmunofluorescencehistochemistry.ThestainingpatternpresentincellbodiesobtainedwiththeguineapigVGLUT3antiserumisinagreementwiththedescribedexpressionpatternofVGLUT3mRNAThestainingpatternobtainedinbothcellbodiesandnervefiberswiththeguineapigVGLUT3antiserumcoincideswiththedescribeddistributionofVGLUT3immunoreactivityobtainedwithotherVGLUT3antisera(Fremeau,2002;Gras,2002;Sch?fer,2002).PreabsorptionoftheVGLUT3antiserumwiththeimmunogenpeptide(CatalognumberAG320)eliminatesallimmunostaining. |
| SpeciesReactivity | |
| SpeciesReactivityNote | Rat.Itisexpectedthattheantibodymayalsoreactwithmousebasedonsequencehomology(85%).Otherspecieshavenotyetbeentested. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol | - VGLUT3
- VGluT3
- SLC17A8
- DFNA25
|
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Mediatestheuptakeofglutamateintosynapticvesiclesatpresynapticnerveterminalsofexcitatoryneuralcells.Mayalsomediatethetransportofinorganicphosphate. SUBCELLULARLOCATION:Cytoplasmicvesicle,secretoryvesicle,synapticvesiclemembrane(Bysimilarity).Membrane;Multi-passmembraneprotein(Potential).Celljunction,synapse,synaptosome(Bysimilarity). TISSUESPECIFICITY:Expressedinamygdala,cerebellum,hippocampus,medulla,spinalcordandthalamus. SIMILARITY:Belongstothemajorfacilitatorsuperfamily.Sodium/anioncotransporterfamily.VGLUTsubfamily. SIZE:589aminoacids;64991Da |
| MolecularWeight | ~65kDa |