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Millipore/AB1543 | Anti-Synapsin I Antibody/AB1543/50 µL
  • Millipore/AB1543 | Anti-Synapsin I Antibody/AB1543/50 µL

Millipore/AB1543 | Anti-Synapsin I Antibody/AB1543/50 µL

價(jià)格: ￥4188.00 市場(chǎng)價(jià): 6980.00
貨號(hào): AB1543
品牌: Millipore
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    • Description
      CatalogueNumberAB1543
      BrandFamilyChemicon®
      TradeName
      • Chemicon
      DescriptionAnti-SynapsinIAntibody
      AlternateNames
      • Synapsin-1
      BackgroundInformationSynapsinIisamemberofthesynapsinfamily.Synapsinsareneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsoftheSynapsinIgenemaybeassociatedwithXlinkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.
      ProductInformation
      FormatSerum
      Control
      • Mousehippocampalprimaryneurons,Mousebrainlysates,PC-12cells.
      PresentationRabbitpolyclonalantiseruminbuffercontainingnopreservatives.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20oCfromdateofreceipt.
      HandlingRecommendations:Uponreceiptandpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationDetectSynapsinIusingthisAnti-SynapsinIAntibodyvalidatedforuseinIC,IH(P),IP&WB.
      KeyApplications
      • Immunocytochemistry
      • Immunohistochemistry(Paraffin)
      • Immunoprecipitation
      • WesternBlotting
      ApplicationNotesWesternblotting:
      1:200ofapreviouslotwasusedforlabeledProteinA,1:1,000dilutionforECL.

      Immunocytochemistry:
      1:500-1:2,000dilutionofapreviouslotwasused.

      Immunoprecipitation:
      5μLofapreviouslotquantitativelyimmunoprecipitatedallsynapsinin200μgofratbrain.

      Optimalworkingdilutionsmustbedeterminedbytheenduser.
      BIOLOGicalInformation
      ImmunogenSynapsinI(mixtureofIa&Ib)purifiedfrombovinebrain.
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostRabbit
      SpecificitySynapsinI(Mrof80,000and77,000).ImmunolabelingisblockedbypreadsorptionofantibodywithSynapsinI.SynapsinislocatedonlyinbrainnerveterminalandisanexcellentMarkerforsynapses.
      SpeciesReactivity
      • Bovine
      • Human
      • Mouse
      • Rat
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryThisgeneisamemberofthesynapsingenefamily.Synapsinsencodeneuronalphosphoproteinswhichassociatewiththecytoplasmicsurfaceofsynapticvesicles.Familymembersarecharacterizedbycommonproteindomains,andtheyareimplicatedinsynaptogenesisandthemodulationofneurotransmitterrelease,suggestingapotentialroleinseveralneuropsychiatricdiseases.Thismemberofthesynapsinfamilyplaysaroleinregulationofaxonogenesisandsynaptogenesis.Theproteinencodedservesasasubstrateforseveraldifferentproteinkinasesandphosphorylationmayfunctionintheregulationofthisproteininthenerveterminal.MutationsinthisgenemaybeassociatedwithX-linkeddisorderswithprimaryneuronaldegenerationsuchasRettsyndrome.Alternativelysplicedtranscriptvariantsencodingdifferentisoformshavebeenidentified.
      GeneSymbol
      • SYN1
      • SYN1a
      • SYNI
      • SYN1b
      PurificationMethodUnpurified
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P17600#Neuronalphosphoproteinthatcoatssynapticvesicles,bindstotheCytoskeleton,andisbelievedtofunctionintheregulationofneurotransmitterrelease.ThecomplexformedwithNOS1andCAPONproteinsisnecessaryforspecificnitric-oxidfunctionsatapresynapticlevel.
      SIZE:705aminoacids;74111Da
      SUBUNIT:Homodimer.InteractswithCAPON.FormsaternarycomplexwithNOS1(Bysimilarity).
      SUBCELLULARLOCATION:Celljunction,synapse.
      PTM:Substrateofatleastfourdifferentproteinkinases.Itisprobablethatphosphorylationplaysaroleintheregulationofsynapsin-1inthenerveterminal.PhosphorylateduponDNAdamage,probablybyATMorATR.
      DISEASE:SwissProt:P17600#DefectsinSYN1areacauseofX-linkedrecessiveepilepsyassociatedwithvariablelearningdisABIlitiesandbehaviordisorders[MIM:300491].
      SIMILARITY:SwissProt:P17600##Belongstothesynapsinfamily.
      MolecularWeight77&80kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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