| Immunogen | Denaturedtyrosinehydroxylasefromratpheochromocytoma(denaturedbysodiumdodecylsulfate). |
| Host | Rabbit |
| Specificity | Tyrosinehydroxylase.Bywesternblot,AB152selectivelabelsasinglebandatapproximately62kDa(reduced)correspondingtoTyrosineHydroxylase.Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
| SpeciesReactivity | - Human
- Rat
- Mouse
- Feline
- Ferret
- Squid
- Drosophila
- Mollusk
|
| SpeciesReactivityNote | Rat,mouse,ferret,feline,Aplysia(marinemollusc).Itisexpectedthattheantibodywillreactwithmostmammalianandmanynon-mammalianspecies.Ithasbeenreportedthatthisantibodydoesnotworkonparaffinembeddedhumantissue. |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Tyrosinehydroxylaseisinvolvedintheconversionoftyrosinetodopamine.Astherate-limitingenzymeinthesynthesisofcatecholamines,tyrosinehydroxylasehasakeyroleinthephysiologyofadrenergicneurons. |
| GeneSymbol | |
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:SwissProt:P07101#Playsanimportantroleinthephysiologyofadrenergicneurons. COFACTOR:Fe(2+)ion. SIZE:528aminoacids;58524Da TISSUESPECIFICITY:Mainlyexpressedinthebrainandadrenalglands. DISEASE:SwissProt:P07101#DefectsinTHarethecauseofautosomalrecessiveSegawasyndrome[MIM:605407];alsoknownasDOPA-responsivedystonia.Typically,itbeginsinchildhoodoradolescencewithprogressivedifficultyinwalkingand,insomecases,spasticity.Somecasespresentwithparkinsoniansymptomsininfancyandarereferredtoasautosomalrecessiveinfantileparkinsonism. SIMILARITY:SwissProt:P07101##Belongstothebiopterin-dependentaromaticaminoacidhydroxylasefamily. |
| MolecularWeight | 62kDa |