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Millipore/09-407 | Anti-phospho-TIE2/TEK (Tyr992) Antibody/09-407/100 µL
  • Millipore/09-407 | Anti-phospho-TIE2/TEK (Tyr992) Antibody/09-407/100 µL

Millipore/09-407 | Anti-phospho-TIE2/TEK (Tyr992) Antibody/09-407/100 µL

價(jià)格: ￥3696.00 市場(chǎng)價(jià): 6160.00
貨號(hào): 09-407
品牌: Millipore
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    • Description
      CatalogueNumber09-407
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-TIE2/TEK(Tyr992)Antibody
      AlternateNames
      • VMCM
      • TIE-2
      • CD202B
      BackgroundInformationTIE2(TEK,tyrosinekinasewithIgandEGFhomologydomains2),areceptortyrosinekinase(RTK),isexpressedalmostexclusivelyinendothelialcellsandprimitivehematopoieticstemcellsinmice,ratsandhumans.Thisreceptorpossessesauniqueextracellulardomaincontainingtwoimmunoglobulin-likeloopsseparatedbythreeepidermalgrowthfactor-likerepeatsthatareconnectedtothreefibronectintypeIII-likerepeats.TheligandforthereceptorisAngiopoietin1(Ang-1),whichcancauseDok-R/Dok-2toassociatewithTek,resultingintyrosinephosphorylationofDok-RandthesubsequentrecruitmentofNckandthep21-activatingkinase(Pak/Pak1)totheactivatedreceptor.DefectsinTIE2areassociatedwithinheritedvenousmalformations.TheTIE2signalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.
      ProductInformation
      FormatPurified
      Control
      • pervanadate-treatedHUVECcelllysate
      PresentationAffinitypurifiedrabbitpolyclonalIgGinstoragebuffercontainingPBSwith0.05%sodiumazidein50%glycerol.
      StorageandShippingInformation
      StorageConditionsStablefor1yearat-20°Cfromdateofreceipt.
      HandlingRecommendations:Uponreceipt,andpriortoremovingthecap,centrifugethevialandgentlymixthesolution.Aliquotintomicrocentrifugetubesandstoreat-20°C.Avoidrepeatedfreeze/thawcycles,whichmaydamageIgGandaffectproductperformance.
      Applications
      ApplicationAnti-phospho-TIE2/TEK(Tyr992)Antibodyisanantibodyagainstphospho-TIE2/TEK(Tyr992)foruseinIH,IP&WB.
      KeyApplications
      • Immunohistochemistry
      • Immunoprecipitation
      • WesternBlotting
      BIOLOGicalInformation
      ImmunogenSyntheticpeptideencompassingandincludingphosphorylatedTyr992ofhumanTIE2.
      HostRabbit
      SpecificityRecognizesTIE2/TEKphosphorylatedonTyr992.
      IsotypeIgG
      SpeciesReactivity
      • Human
      SpeciesReactivityNoteMouseandratexpectedtoreactbasedon100%homologyofimmunogen.
      AntibodyTypePolyclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheTEKreceptortyrosinekinaseisexpressedalmostexclusivelyinendothelialcellsinmice,rats,andhumans.Thisreceptorpossessesauniqueextracellulardomaincontaining2immunoglobulin-likeloopsseparatedby3epidermalgrowthfactor-likerepeatsthatareconnectedto3fibronectintypeIII-likerepeats.Theligandforthereceptorisangiopoietin-1.DefectsinTEKareassociatedwithinheritedvenousmalformations;theTEKsignalingpathwayappearstobecriticalforendothelialcell-smoothmusclecellcommunicationinvenousmorphogenesis.TEKiscloselyrelatedtotheTIEreceptortyrosinekinase.
      GeneSymbol
      • TEK
      • CD202B
      • TIE2
      • VMCM1
      • VMCM
      • hTIE2
      • CD202b
      • TIE-2
      Modifications
      • Phosphorylation
      PurificationMethodDoubleaffinitypurificationoverbothnon-phospho-peptidecolumnfollowedbyphopshorylatedpeptidecolumn.
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:Q02763#Thisproteinisaproteintyrosine-kinasetransmembranereceptorforangiopoietin1.ItmayconstitutetheearliestmammalianendothelialcelllineageMarker.Probablyregulatesendothelialcellproliferation,differentiationandguidestheproperpatterningofendothelialcellsduringbloodvesselformation.
      SIZE:1124aminoacids;125811Da
      SUBCELLULARLOCATION:Membrane;Single-passtypeImembraneprotein.
      TISSUESPECIFICITY:PredominantlyexpressedinendothelialcellsandtheirProgenitors,theangioblasts.Hasbeendirectlyfoundinplacentaandlung,withalowerlevelinumbilicalveinendothelialcells,brainandkidney.
      DISEASE:SwissProt:Q02763#DefectsinTEKareacauseofdominantlyinheritedvenousmalformations(VMCM)[MIM:600195];anerrorofvascularmorphogenesischaracterizedbydilated,serpiginouschannels.
      SIMILARITY:SwissProt:Q02763##Belongstotheproteinkinasesuperfamily.Tyrproteinkinasefamily.Tiesubfamily.&Contains3EGF-likedomains.&Contains3fibronectintype-IIIdomains.&Contains2Ig-likeC2-type(immunoglobulin-like)domains.&Contains1proteinkinasedomain.
      MolecularWeight145kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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