| Immunogen | KLH-conjugatedlinearproteincorrespondingtohumanRBL2atandaroundtheC-terminus. |
| Epitope | C-terminus |
| Concentration | PleaserefertotheCertificateofAnalysisforthelot-specificconcentration. |
| Host | Rabbit |
| Specificity | ThisantibodyrecognizesRBL2atandaroundtheC-terminus. |
| SpeciesReactivity | |
| SpeciesReactivityNote | Proventoreactwithhuman.Predictedtoreactwithrat,horse,chimpanzee,ape,anddogbasedonsequencehomology.Mouse(95%). |
| AntibodyType | PolyclonalAntibody |
| EntrezGeneNumber | |
| GeneSymbol | - RBL2
- P130
- PRB2
- RB2
- RBR-2
- Rb2
- p130
|
| PurificationMethod | AffinityPurfied |
| UniProtNumber | |
| UniProtSummary | FUNCTION:Keyregulatorofentryintocelldivision.Directlyinvolvedinheterochromatinformationbymaintainingoverallchromatinstructureand,inparticular,thatofconstitutiveheterochromatinbystABIlizinghistonemethylation.RecruitsandtargetshistonemethyltransferasesSUV420H1andSUV420H2,leADIngtoepigenetictranscriptionalrepression.ControlshistoneH4"Lys-20"trimethylation.Probablyactsasatranscriptionrepressorbyrecruitingchromatin-modifyingenzymestopromoters.PotentinhibitorofE2F-mediatedtrans-activation,associatespreferentiallywithE2F5.BindstocyclinsAandE.BindstoandmaybeinvolvedinthetransformingcapacityoftheadenovirusE1Aprotein.Mayactasatumorsuppressor.
SIZE:1139aminoacids;128367Da
SUBUNIT:InteractswithAATF.InteractswithSUV420H1andSUV420H2(Bysimilarity).InteractswithRINT1.
SUBCELLULARLOCATION:Nucleus.
PTM:DuringG0andearlyG1phaseofthecellcycle,phosphorylatedonSer-639andon5siteswithinthedomainB.PhosphorylationonSer-672inG1leadstoitsubiquitin-dependentproteolysis.
SIMILARITY:Belongstotheretinoblastomaprotein(RB)family.
MISCELLANEOUS:G0-restrictedexpression. |
| MolecularWeight | 130kDa |