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Millipore/05-481 | Anti-phospho-MAP Kinase1/2 Antibody/05-481/100 µg
  • Millipore/05-481 | Anti-phospho-MAP Kinase1/2 Antibody/05-481/100 µg

Millipore/05-481 | Anti-phospho-MAP Kinase1/2 Antibody/05-481/100 µg

價格: ￥3948.00 市場價: 6580.00
貨號: 05-481
品牌: Millipore
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    • Description
      CatalogueNumber05-481
      BrandFamilyUpstate
      TradeName
      • Upstate
      DescriptionAnti-phospho-MAPKinase1/2Antibody
      AlternateNames
      • Extracellularsignal-regulatedkinase
      • Insulin-stimulatedMAP2kinase
      • MAPkinase1
      • MAPK1
      • Microtubule-associatedprotein2kinase
      • extracellularsignal-relatedkinase1
      • mitogen-activatedproteinkinase3
      BackgroundInformationTheextracellularsignal-regulatedkinases1and2(ERK1andERK2),alsocalledp44andp42MAPkinases,aremembersoftheMitogenActivatedProteinKinase(MAPK)familyofproteinsfoundinalleukaryotes.Becausethe44kDaERK1andthe42kDaERK2arehighlyhomologousandbothfunctioninthesameproteinkinasecascade,thetwoproteinsareoftenreferredtocollectivelyasERK1/2orp44/p42MAPkinase.TheERK1/2signalingcascadehasbeenshowntobeacriticalregulatorofcelldifferentiation,cellphysiologyandneuronalfunction.AberrantcontrolofERK1/2activityhasbeenimplicatedinavarietyofpathologicalconditions,includingcancerandautoimmunediseases,andefficientstudymethodsareindemand.Extracellularsignal/mitogenactivatedproteinkinases(erk/MAPK)areagroupofproline-directedserine/threoninekinasesthatareactivatedbydualphosphorylationofconservedthreonineandtyrosineresidueswithinacharacteristicTXYpeptidemotif.Themitogen-activatedkinaseserk1(MAPK1)anderk2(MAPK2)acquirefullenzymaticactivityuponphosphorylationofboththreonineandtyrosineresidueswithinthesequencemotifTEY.
      ProductInformation
      FormatPurified
      Control
      • IncludedPositiveControlLysate:Catalog#12-302,EGF-stimulatedA431lysate.Add2.5μLof2-mercaptoethanol/100μLoflysateandboilfor5minutestoreducethepreparation.Load20μg(20μL)ofreducedlysateperlaneforminigels.
      PresentationPurifiedmousemonoclonalIgG1klyophilizedfrom1mL2xPBS/0.09%Na-azide/PEGandSucrose.
      Reconstitutewith1mLH2O(15min,RT)forafinalconcentrationof100μg/mL.
      StorageandShippingInformation
      StorageConditionsStablefor1yearatfromdateofreceipt.
      Applications
      ApplicationDetectphospho-MAPKinase1/2usingthisAnti-phospho-MAPKinase1/2validatedforuseinWB,IP,ELISA&IC.
      KeyApplications
      • WesternBlotting
      • Immunoprecipitation
      • ELISA
      • Immunocytochemistry
      ApplicationNotesImmunoprecipitation:Use1-10μgperimmuno-precipitation.
      BIOLOGicalInformation
      ImmunogenKLH-conjugatedphosphopeptidecontainingthepTEpYmotifofErk1andErk2.Clone:12D4
      Cloneclone12D4
      ConcentrationPleaserefertotheCertificateofAnalysisforthelot-specificconcentration.
      HostMouse
      SpecificitySpecificforphosphorylated(activated)Erk1andErk2.AntibodyrecognitionrequiresphosphorylationofboththethreonineandtyrosineresiduesofErk1/Erk2andwillnotinteractwiththenon-phosphorylatedformoftheproteins.DoesnotcrossreactwithactivatedSAPKinase1or2.
      IsotypeIgG1κ
      SpeciesReactivity
      • Human
      • Mouse
      • Rat
      • Avian
      • Canine
      AntibodyTypeMonoclonalAntibody
      EntrezGeneNumber
      EntrezGeneSummaryTheproteinencodedbythisgeneisamemberoftheMAPkinasefamily.MAPkinases,alsoknownasextracellularsignal-regulatedkinases(ERKs),actinasignalingcascadethatregulatesvariouscellularprocessessuchasproliferation,differentiation,andcellcycleprogressioninresponsetoavarietyofextracellularsignals.Thiskinaseisactivatedbyupstreamkinases,resultinginitstranslocationtothenucleuswhereitphosphorylatesnucleartargets.Alternativelysplicedtranscriptvariantsencodingdifferentproteinisoformshavebeendescribed....
      GeneSymbol
      • MAPK3
      • MGC20180
      • ERT2
      • HUMKER1A
      • p44-MAPK
      • PRKM3
      • ERK1
      • p44erk1
      • p44mapk
      • P44MAPK
      • HS44KDAP
      • p44-ERK1
      • P44ERK1
      • ERK-1
      Modifications
      • Phosphorylation
      PurificationMethodThiophilicadsoptionandsizeexclusionchromatography
      UniProtNumber
      UniProtSummaryFUNCTION:SwissProt:P27361#Involvedinboththeinitiationandregulationofmeiosis,mitosis,andpostmitoticfunctionsindifferentiatedcellsbyphosphorylatinganumberoftranscriptionfactorssuchasELK-1.PhosphorylatesEIF4EBP1;requiredforinitiationoftranslation.Phosphorylatesmicrotubule-associatedprotein2(MAP2).PhosphorylatesSPZ1(Bysimilarity).Phosphorylatesheatshockfactorprotein4(HSF4).
      COFACTOR:Magnesium(Bysimilarity).
      SIZE:379aminoacids;43136Da
      SUBUNIT:InteractswithMORG1(Bysimilarity).BindstoHIV-1Nef.Thisinteractioninhibitsitskinaseactivity.InteractswithHSF4.
      DOMAIN:SwissProt:P27361TheTXYmotifcontainsthethreonineandtyrosineresidueswhosephosphorylationactivatestheMAPkinases.
      PTM:DuallyphosphorylatedonThr-202andTyr-204,whichactivatestheenzyme.
      SIMILARITY:Belongstotheproteinkinasesuperfamily.CMGCSer/Thrproteinkinasefamily.MAPkinasesubfamily.&Contains1proteinkinasedomain....
      MolecularWeight42-44kDa
      PhysicochemicalInformation
      Dimensions
      MaterialsInformation
      MaterialsInformation
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