| Immunogen | Syntheticpeptidecorrespondingtoresiduesofhumanpro-Caspase-6. |
| Clone | EP1325Y |
| Host | Rabbit |
| Specificity | Thisantibodyrecognizespro-Caspase6. |
| Isotype | IgG |
| SpeciesReactivity | |
| SpeciesReactivityNote | Proventoreactinhuman. |
| AntibodyType | MonoclonalAntibody |
| EntrezGeneNumber | |
| EntrezGeneSummary | Thisgeneencodesaproteinwhichisamemberofthecysteine-asparticacidprotease(caspase)family.Sequentialactivationofcaspasesplaysacentralroleintheexecution-phaseofcellapoptosis.Caspasesexistasinactiveproenzymeswhichundergoproteolyticprocessingatconservedasparticresiduestoproducetwosubunits,largeandsmall,thatdimerizetoformtheactiveenzyme.Thisproteinisprocessedbycaspases7,8and10,andisthoughttofunctionasadownstreamenzymeinthecaspaseactivationcascade.Alternativesplicingofthisgeneresultsintwotranscriptvariantsthatencodedifferentisoforms.[providedbyRefSeq].
|
| GeneSymbol | |
| PurificationMethod | Unpurified |
| UniProtNumber | |
| UniProtSummary | FUNCTION:InvolvedintheactivationcascadeofcaspasesresponsIBLeforapoptosisexecution.Cleavespoly(ADP-ribose)polymeraseinvitro,aswellaslamins.Overexpressionpromotesprogrammedcelldeath.
CATALYTICACTIVITY:StrictrequirementforAspatpositionP1andhasapreferredcleavagesequenceofVal-Glu-His-Asp-|-.
ENZYMEREGULATION:ActivationissuppressedbyphosphorylationatSer-257.Ref.5
SUBUNITSTRUCTURE:Heterotetramerthatconsistsoftwoanti-parallelarrangedheterodimers,eachoneformedbya18kDa(p18)anda11kDa(p11)subunit.
SUBCELLULARLOCATION:Cytoplasm.
PTM:Cleavagesbycaspase-3,caspase-8or-10generatethetwoactivesubunits.
SEQUENCESIMILARITY:BelongstothepeptidaseC14Afamily.
|
| MolecularWeight | ~35kDa |